Showing posts with label Ageing. Show all posts
Showing posts with label Ageing. Show all posts

April 1, 2020

Is Worrying About Getting The Coronavirus Make your Hair Gray?

  • Stress can cause hair to gray prematurely by affecting the stem cells that are responsible for regenerating hair pigment.
  • The findings give insights for future research into how stress affects stem cells and tissue regeneration.
Mature man looking in bathroom mirror at the gray hair in his beardThe study yielded insights into why hair turns gray.  Jay Yuno / iStock / Getty Images Plus
Stress can have a variety of negative effects on the body. The idea that acute stress can cause hair to turn gray is a popular belief. But until now, that link wasn’t scientifically proven.
Hair color is determined by cells called melanocytes, which produce the pigment melanin. New melanocytes are made from melanocyte stem cells that live within the hair follicle at the base of the hair strand. As we age, these stem cells gradually disappear. The hair that regrows from hair follicles that have lost melanocyte stem cells has less pigment and appears gray.
Researchers set out to determine if stress could also cause hair to gray, and if so, how. The study was funded in part by NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other NIH components. The findings appeared in Nature on January 22, 2020.
The research team, led by Dr. Ya-Chieh Hsu of Harvard University, used mice to examine stress and hair graying. The mice were exposed to three types of stress involving mild, short-term pain, psychological stress, and restricted movement. All caused noticeable loss of melanocyte stem cells and hair graying.
Having established a link between stress and graying, the scientists then explored several potential causes. They first tested whether immune attack might be responsible for depleting melanocyte stem cells. But stressing mice with compromised immune systems still led to hair graying. The team then investigated the role of the stress hormone corticosterone, but altering its levels didn’t affect stress-related graying.
The researchers eventually turned to the neurotransmitter noradrenaline, which, along with corticosterone, was elevated in the stressed mice. They found that noradrenaline, also known as norepinephrine, was key to stress-induced hair graying. By injecting noradrenaline under the skin of unstressed mice, the researchers were able to cause melanocyte stem cell loss and hair graying.
Noradrenaline is produced mostly by the adrenal glands. However, mice without adrenal glands still showed stress-related graying. Noradrenaline is also the main neurotransmitter of the sympathetic nervous system, which is responsible for the “fight-or-flight” reaction in response to stress.
The team ultimately discovered that signaling from the sympathetic nervous system plays a critical role in stress-induced graying. Sympathetic nerves extend into each hair follicle and release noradrenaline in response to stress. Normally, the melanocyte stem cells in the follicle are dormant until a new hair is grown. Noradrenaline causes the stem cells to activate.
Using florescent labelling, the researchers observed the stem cells change to melanocytes and migrate away from their reserve in the hair follicle. With no remaining stem cells, no new pigment cells can be made, and any new hair becomes gray, then white. 
“When we started to study this, I expected that stress was bad for the body — but the detrimental impact of stress that we discovered was beyond what I imagined,” Hsu says. “After just a few days, all of the melanocyte stem cells were lost. Once they’re gone, you can’t regenerate pigments anymore. The damage is permanent.”
The authors highlight the need to further study the interactions between the nervous system and stem cells in different tissues and organs. The knowledge gained in this work will be useful in future investigations into the impact of stress on the body and the development of new interventions.
—by Erin Bryant

April 30, 2018

Former Beautiful Model Eaten By Scabies inGeorgia Nursing Home [IsThat What's Waiting for Us?]

LAFAYETTE, Georgia — A Georgia nursing home resident who died from a scabies infestation is believed to have been eaten alive over the course of months or years.
According to a pending lawsuit filed by the family, 93-year-old Rebecca Zeni died in 2015 from scabies at the facility. The autopsy report shows the cause of death as “septicemia due to crusted scabies.” State health officials were notified about a scabies outbreak at the nursing home multiple times but did not inspect the LaFayette, Ga. facility.
A forensic pathologist who reviewed the case estimates millions of parasitic mites essentially ate Zeni alive over several months or possibly years.
Zeni’s family say their mother lived the American dream. She worked in a naval yard during World War II; modeled in New York City, and worked at a TV station in Chicago.
Zeni’s daughter, who declined to be interviewed on-camera, says she moved her mother into Shepherd Hills Nursing Home in 2010. Health records show Zeni suffered from dementia.
“I don’t understand how you can allow a human being to suffer needlessly,” said Mike Prieto, one of two attorneys representing Zeni’s family in a lawsuit against Pruitt Health, which operates Shepherd Hills Nursing Home.
Scabies is a painful, but treatable skin condition caused when parasitic mites burrow into your skin, lay eggs and survive off of your body. Pictures of Zeni before her death show skin flaking off and one of her hands blackened.
Stephen Chance, another attorney representing the family, claims staff was told not to touch Zeni’s hand. “There was a conversation at this nursing home with a healthcare provider about being careful about touching Ms. Zeni’s hand for fear that it might fall off her body,” claims Chance in an interview.
Forensic pathologist Dr. Kris Sperry, a former chief medical examiner at the Georgia Bureau of Investigation, reviewed Zeni’s autopsy report. He says he’s personally conducted more than 6,000 autopsies and has supervised more than 80,000 others.
“This is one of the most horrendous things I’ve ever seen in my career as a forensic pathologist,” Sperry said.
Sperry estimates hundreds of millions of mites were living inside Zeni at the time of her death. He doesn’t think it’s an exaggeration to assume she was essentially eaten alive and that she likely died a painful death.
“Having seen what I’ve seen with Ms. Zeni, I think that is frankly a good characterization,” said Sperry. “I would seriously consider calling this a homicide by neglect.”
Pruitt Health’s chairman, communications director and an attorney representing the company did not respond to request for comment. According to a response to the lawsuit, Pruitt attorneys denied all of the claims outlined in Zeni’s lawsuit, writing “[Pruitt Health] denies that it is a medical or healthcare provider and it, therefore, owed no legal duty to Plaintiff or Ms. Rebecca Zeni for which it could be held liable in this litigation.”

Missed Opportunities

According to records obtained from the Georgia Department of Public Health (DPH), state officials were notified of a scabies outbreak at Zeni’s facility in 2013 and 2015 before her death.
In its June 4th 2015 report, it shows at least 35 residents and staff were exposed to scabies. Instead of inspecting the facility in person, a state health department employee emailed a manual to the facility on how to treat scabies. Eleven days later, Zeni passed away.
According to DPH spokesperson Nancy Nydam, the agency isn’t required to inspect facilities when its notified about a scabies infestation. Despite the low reported outbreaks, Nydam says the agency considers scabies infestations “not necessarily uncommon” events at nursing homes.
While DPH records show no reported cases of scabies at Shepherd Hills in 2014, the facility’s own records show otherwise. According to the nursing home’s infection logs submitted into the case file, there were at least seven cases of scabies at the facility on October 22, 2014. DPH has no record of the facility notifying state health officials.
While DPH isn’t required to inspect facilities after learning about an outbreak, Nydam says its typical protocol to alert the Georgia Department of Community Health (DCH), which performs annual inspections of state nursing homes and responds when it receives a complaint from the public.
DPH says it has no record of staff notifying DCH regulators about the outbreak. When asked for documentation showing DCH was notified about scabies or inspection records related to any scabies outbreak at Shepherd Hills, DCH spokesperson Fiona Roberts emailed, “DCH does not have any records responsive to that issue.”
USA TODAY NETWORKAndy Pierrotti, WXIA-TV, Atlanta
Main photo submitted by family to USA

May 23, 2014

10 Myths About Aging, Debunked

The author of 'Getting Older Better' gives practical advice on vital living

posted by Pamela Blair 
The author of 'Getting Older Better' gives practical advice on vital living
Pamela Blair is a holistic psychotherapist, spiritual counselor and personal coach. She has written for numerous magazines and is the author of I Wasn't Ready to Say Goodbye andGetting Older Better.

The author of 'Getting Older Better' gives practical advice on vital living
(following is adapted fromGetting Older Better: The Best Advice Ever on Money, Health, Creativity, Sex, Work, Retirement and More.)

"The media reflects our collective anxiety about growing older. I like to call this the 'misery myth.'"
 — Laura L. Carstensen, Ph.D.

The attitude that surrounds us is that old age in its most problematic sense starts somewhere between 50 or 60. Why is this? Perhaps we still buy into some outdated myths that life after 50 is the beginning of our decline.

Living passionately and well, however, doesn't stop at a certain point in one's life followed by the destructive forces of aging.

(MORE: 'There is No Cure for Aging' — So Embrace It)

To age successfully, we need to be aware of the newer and older myths about aging that our current culture holds true. Here are 10 examples of the myths I've heard and what I know to be true:

Myth: Old women are depressed and lonely.

Truth: Depending on circumstances, we may get sad and lonely from time to time, but theresearch shows that the least lonely and depressed women are over 75.

Myth: Older women are less successful in new pursuits.

Truth: Some of the best and brightest women, though past the half-century mark in years, are still climbing the ladder of success in the world.

(MORE: 2 Ways to Help More People Have Encore Careers)

Myth: Old women have more stress in their lives.

Truth: According to psychologists, older women have more stress-free days than younger ones.

Myth: Growing older is synonymous with the loss of meaning and purpose.

Truth: Research and the elderly themselves are demonstrating that one's later years can be therichest ever in wisdom and spirituality.

(MORE: How to Start a New, More Meaningful Career)

Myth: If you are older and reminiscing about the past or are becoming garrulous about the past, you are exhibiting signs of senility.

Truth: These recollections are natural and appropriate, and their purpose is to resolve conflicts of life and to do a life review.

Myth: The older you get, the faster time passes.

Truth: Mathematically, those proverbial endless summers of your childhood were not even one minute longer than last summer. You have more routines now and routines lend uniformity, which makes it very easy to be oblivious to time.

Myth: Everyone wants to, and should be willing to, hear our wisdom and opinions just because we are older.

Truth: Even though we're older and wiser, we don't necessarily know everything and are OK with that.

Myth: Older women are weak and have to be protected.

Truth: Once the protector myth is conquered, women become whole and authentic. We know that if we accept a limiting role, we violate ourself.

Myth: Creativity is only for the gifted few and our talents dim with age.

Truth: Creativity is not just for geniuses and the gifted. It is the energy that allows us to express ourselves in unique ways; it enables us to view life as an opportunity for exploration and it knows no age.

Myth: All old women are physically passionless and have no interest in being sexual.

Truth: Many older women continue to be passionate about life and maintain an interest in sex.

August 19, 2013

Ireland’s Gilmore Urged to do More About Russia’s Anti-Gay Laws

Eamon Gilmore is being urged to take a stand against Russia's new anti-homosexual laws.
The call comes as supporters of gay marriage take to the streets of Dublin this afternoon in opposition to the bill introduced by President Vladimir Putin which outlaws support for 'non-traditional' relationships.
The annual 'March for Marriage' has been organised by the LGBT group Noisewho want the Tánaiste and Minister for Foreign Affairs to publicly condemn the new laws.
Their spokesperson Max Kryzanowski said the Tánaiste needs to be more vocal on the issue.
Mr Kryzanowski said: "If he has taken a stand, it hasn't been very well publicised and he will find an enormous body of public support if he cares to speak out on this issue and if he cares to use Ireland's considerable clout and our improving record on LGBT equality in the country.
"He will find ready allies among countries in Europe who will speak in concert on this.
"I think he is actually in a position where he can take something of a leadership role.”

January 23, 2013

Gay Seniors Never Comfortable Being OUt Now Are Going Back to The Closet

In terms of academic research, LGBT seniors largely remain in the closet. Only a few studies have attempted to shed light on the needs of aging LGBT adults.
Experts in the field of gerontology point to several factors behind the lack of scientific data on this age group. LGBT people were not considered part of the senior population, they said, so questions about sexual orientation or gender identity weren't asked.
The onslaught of AIDS in the 1980s not only devastated a generation of gay and bisexual men, it also diverted the LGBT community's attention and scarce research funding toward combating the deadly disease.
"The money for it simply dried up in the 1990s and didn't come back until the end of that decade," said Marcy Adelman, Ph.D., who has focused on LGBT aging since the 1970s. "The community wasn't in a position to focus on aging when struggling so hard to keep everybody alive. I don't think Washington was particularly friendly to LGBT aging research."
Now, due to treatment advances, people with HIV are living well past their 50s. They are aging alongside other LGBT baby boomers, many of whom have been out of the closet for decades and are demanding services as they enter retirement age.
The result is an increased attention on studying LGBT seniors and addressing their concerns. Entities from the National Institutes of Health to AARP have funneled resources toward LGBT adults.
"We are finally starting to talk about these issues from a research position," said Brian de Vries, a gay man who is a professor of gerontology at San Francisco State University. "AIDS happened and researchers were just siphoned away and turned their attention to the experiences of people living with, and at that time dying from, HIV. I think it has only been in the last 10 years or so that we have found our way back to an appreciation of aging within the LGBT community."
He recalled attending a lecture in the mid 1980s about gay men and aging where an audience member asked if "those terms are mutually incompatible 'gay' and 'aging.' It really struck me that somebody would make a comment like that.
"So many of us were dying during that time, so the idea of aging seemed luxurious," he added. "Given what the circumstances were, people thought it was almost not possible. I think that is part of the issue for why we were late to the game."
Early last decade de Vries, 56, helped establish and co-chaired Rainbow Research, an LGBT interest group within the Gerontological Society of America. He also took part in 2006 and 2010 in a Met Life study focused on LGBT seniors.
Called "Still Out, Still Aging," "it was one of the only national representative studies of LGBT boomers," said de Vries.
It first looked at the needs of 1,000 LGBT baby boomers. A follow-up study then compared 1,200 LGBT boomers against 1,200 from the general population.
"It was one of the very few studies that allowed us to compare LGBT people with heterosexuals," de Vries said.

One of the lead authors of the Met Life study, and a co-founder of the Rainbow Research group, was Karen I. Fredriksen-Goldsen, Ph.D., a professor at the University of Washington and director of the Institute for Multigenerational Health.

More than a third of the two million LGBT seniors in our nation are clinically depressed, according More than a third of the two million LGBT seniors in our nation report depression and one half have a known disability, according to the recent federally funded Aging and Health Report: Disparities and Resilience among Lesbian, Gay, Bisexual, and Transgender Older Adults. 

Fredriksen-Goldsen, 55, an out lesbian, also received funding in 2009 from the NIH and the National Institute on Aging to conduct a national survey on the needs of LGBT seniors. More than 2,500 LGBT adults ranging in age from 50 to 95 took part.
The findings were published in 2010, and that same year, the U.S. Department of Health and Human Services funded the creation of the National Resource Center on LGBT Aging.
As for why there had been relatively little LGBT aging research done in the past, Fredriksen-Goldsen said, "A lot of it has been just very rampant invisibility colliding with the stereotype that LGBT people aren't seniors."
Her latest project is to study the specific needs of LGBT seniors in San Francisco. As the B.A.R. noted in October, the recently formed LGBT Aging Policy Task Force hired her to oversee the creation of an online survey and analyze the data. A variety of government and private sources have provided $60,000 to fund the work, and an advisory committee of local leaders is assisting with it.
"I am really excited to be working with the city of San Francisco and excited to move the research forward and identify what some of the needs are for some of the most under-represented groups in our community," she said.
Her first task was to study the responses from 295 San Francisco residents who took part in the federally funded Caring and Aging with Pride research project. She was in San Francisco last week to present her findings, and a report based on her work can be downloaded from the task force's website at .
Most of the respondents, 85 percent, were white, and 70 percent were male. The majority lived alone, didn't have children, and were renters.


Dr. Huysman, a psychologist and one of the country’s leading authorities on senior care issues, says that the landmark Health and Aging study underscores the needs of the LGBT senior and boomer population, many of them facing severe situations and, fearing discrimination, are actually being forced back into the closet.

The results are an "initial snapshot," and more information is needed on LGBT seniors of color and transgender people, said Fredriksen-Goldsen.
The task force plans to put particular focus on reaching LGBT adults in those communities when it launches the online survey, which will be in English, Spanish, and Chinese, in late February. It has asked for final analysis by July.
"I haven't had an opportunity before to work as closely and go into the kind of depth as we are going to go in San Francisco," said Fredriksen-Goldsen. "We really want to understand what is happening within very specific communities among LGBT adults."

December 1, 2012

Jude Law Happy to Loose His Middle Age Virginity

jude law aging
It’s been my experience that as much as I hate it, the older I got the easier it was to score while I was single. Meaning I understand what Jude is trying to say about his getting older.  On the other hand one knows that when we hit middle age no matter how successful we are or not in meeting guys, the clock is running and 40-80 is only a few numbers away. At the same time that we might attract people, hopefully we have become more  discerning and cautious, which will for against us been paired after certain age. 

If you have a different point of view, you have plenty of space down below to have your feelings known.  adamfoxie*
  wrote yesterday about  Jude Law satisfaction with his getting older:

Jude Law is happy that he was cast as Keira Knightley‘s unattractive husband in Anna Karenina, at least according to a New York Timesprofile that’s making the rounds today for his quote about no longer being a “pretty young thing.” In some ways, his reflections on aging in Hollywood sound like things we’ve heard from actresses like Jennifer Aniston and Julianne Moore–for whom aging has brought confidence and new perspective–except for the parts about all of his opportunities.
Law discussed his age in relation to his role in Anna Karenina–for which the Times thinks he would have been cast as the lover, not the pious husband, just a few years ago:
“In a weird way, it’s kind of a relief to think, ‘Oh, I know I’m not that young sort of pretty thing anymore,’ ” he said. “It’s quite nice talking about what it was like to be the young pretty thing, rather than being it.”
“I feel kind of more confident, more settled as a human being, more settled in my own skin.” When he was younger, he said, he longed to be taken seriously but found that some of his roles did not allow him to do that. Being older, “you are allowed to be an actor, and the parts you get are more interesting.”
The profile also paints a nasty picture of Law’s tabloid-ridden past, something that no doubt reinforces his happiness with this “new phase in his life,” as T Magazine calls it:
“They had kind of stripped me and my relationships bare — there was nothing left to write,” Law said. “And there is only so much laundry one has, in the end, to be washed in public.”
How liberating, too, he said, to be that much older and not have to maintain an impossible image of perfection. Confronted with a rack of clothes at the photo shoot for this article, he told me his reaction had been, “Look, tell me what I’m wearing — I really don’t care.”
He added: “I don’t have a lot of time anymore for standing around choosing outfits. I’m too long in the tooth for that now.”
It’s hard to buy that Law has lost his cache as an attractive actor, and while he’s far from “long in the tooth” by most peoples’ standards–he turns 40 next month–in Hollywood, it’s true that he’s getting up in his years.
And while it’s nice to see graceful, happy examples of aging–especially in Hollywood, where it’s rarely the case–it’s hard not to notice the contract between his situation and many actresses’.
Take Ashley Judd: For her, the “new phase of life” that was her forties involved speculation about her “puffy face,” cosmetic surgery, and weight.
“When my 2012 face looks different than it did when I filmed Double Jeopardy in 1998,” shewrote in the Daily Beast, “I am accused of having ‘messed up’ my face (polite language here, the F word is being used more often), with a passionate lament that ‘Ashley has lost her familiar beauty audiences loved her for.’” And that’s one of the kinder examples of tabloid coverage she’s gotten since losing her status as “pretty young thing.”
For Jude Law, aging has also come with professional opportunities and a softer light in the media. For women, the trade-off of gaining all that wisdom tends to be losing out on their careers, and often getting mauled by the media–regardless of how they look. We’re happy for him; we just wish that women got a fair shot at having the same.

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